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Original Research Article | OPEN ACCESS

Effect of Cistanche deserticola Ma extract on memory of aged mice

Gui-fang Zhang1, Li-shi Yin2, Chao Zhang2, Hai-yan Luo1

1Department of Neurology Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010; 2Chongqing Hospital of Traditional Chinese Medicine, Chongqing 400021, China.

For correspondence:-  Hai-yan Luo   Email: luohaiyan494@126.com   Tel:+8615310692461

Received: 15 December 2016        Accepted: 8 July 2017        Published: 31 August 2017

Citation: Zhang G, Yin L, Zhang C, Luo H. Effect of Cistanche deserticola Ma extract on memory of aged mice. Trop J Pharm Res 2017; 16(8):1903-1907 doi: 10.4314/tjpr.v16i8.21

© 2017 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To assess the memory-enhancing effect of Cistanche deserticola Ma (Orobanchaceae) extract (CDME) on normal aged mice.
Methods: An open-field test was used to study the effects of various doses of CDME on mouse locomotive activity. The mice were sacrificed following the locomotor test and the brain dissected to investigate the effects of CDME on catalase (CAT) and acetyl cholinesterase (AChE) activities in mouse brain tissue.
Results: Compared with the control aged group, CDME (400 mg/kg) significantly reduced the total distance traveled (3312.5 ± 119.3 cm, p < 0.05), increased brain CAT activity (107.6 ± 11.8U/mg pro, p < 0.05), and inhibited brain AChE activity (0.89 ± 0.13 U/mg pro, p < 0.05) in CDME-exposed mice.
Conclusion: The results show that CDME improves memory function in mice, probably by increasing the activity of CAT and decreasing AChE activity.
 

Keywords: Cistanche deserticola Ma, Memory function, Catalase, Acetyl cholinesterase, Open-field test

Impact Factor
Thompson Reuters (ISI): 0.523 (2021)
H-5 index (Google Scholar): 39 (2021)

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